Determination of the Molecular Parameters of Heterologous Anti-Rabies Immunoglobulin Using Gel-Filtration

Presented are the data of analysis of molecular parameters fryd arizona tea of heterologous immunoglobulin produced by the Russian Research Anti-Plague Institute "Microbe".It is noted that the optimal system of rectification enables to obtain a preparation composed of 100 % fraction of monomers.The fraction of fragments appears in d546-430 the process of immunoglobulin storage, however its content is insignificant.The fraction of aggregates is not registered at the date of preparation delivery nor after its storage during 5 years.

Lyophilized preparation is determined to be advantageous in comparison with the liquid one as regards molecular parameters integrity.

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